Used to acquire trace element line-scans with spot size of 500 or 1000nm and to compare model diffusion profiles in zircon crystals, the NanoSIMS helps analyze cooling and storage conditions in silicic magma reservoir.
Combining high lateral resolution and benchmark sensitivity, NanoSIMS elemental maps give evidence of the association of proteins with biogenic nanocrystals, an example of extracellular biomineralization.
Microbiologists use the NanoSIMS to quantify the metabolic activity and interactions of individual microbes in their environment, without culture.
The NanoSIMS is used to quantify C and N uptake by free-living cells as well as phytoplankton-bacteria, which is key to understanding their response to predicted ocean warming.
The NanoSIMS uniquely permits to complement trace element with high sensitivity and high lateral resolution isotopic ratio mapping of sulfur revealing successive gold-rich fluid inclusions in Pyrite.
Isotopic tracers are used to reveal active oxidation sites by NanoSIMS imaging of cross-sections near the surface. The NanoSIMS is also a tool of choice for mapping light elements (B, 2H) even at low concentrations.
Used to analyze plasmon-driven synthesis of gold nanoprisms, the NanoSIMS helps elucidate the details of photochemical growth mechanisms at the single-nanoparticle level.
Combining high sensitivity with high spatial resolution, the NanoSIMS is used to study the segregation and diffusion of elements in complex materials.
Experiments involving stable isotope labeling and quantitative Multiple Isotope Mass Spectrometry with the NanoSIMS are conducted in order to test the immortal strand hypothesis.
The NanoSIMS allows biologists to view and quantify protein turnover and to follow the fate of biomolecules with intra-cellular resolution.
Revealing the intracellular distributions of biomolecules with a novel NanoSIMS-based methodology
Melanie Brunet, Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at the University of Illinois Urbana−Champaign, working under the guidance of Prof. Mary Kraft, will introduce you to new NanoSIMS-based methodology that significantly enhances the accuracy of intracellular biomolecule visualization. Key take aways include: • Advanced Depth Correction • Accuracy in Imaging • Validation and Impact • Research Applications. .
↓ Duration: 30 minutes
Cécile Becquart, post-doctoral fellow at AstraZeneca, presents recent advances in Antisense Oligonucleotides (ASOs) and the use of NanoSIMS to image and quantify the distribution and accumulation of ASOs within cells. Key take aways include: • Review challenges in terms of delivery of ASOs to specific tissues and inefficient escape from endolysosomal compartments which restrict their use in the clinic • Understand the mechanisms underlying how ASOs enter cells and exit the endolysosomal space • Learn about the specifics NanoSIMS sub-cellular quantitative imaging .
↓ Duration: 18 minutes
Gina Greenidge, Higher Scientist at the National Physical Laboratory (NPL), UK’s National Metrology Institute, presents a study nitrogen fixation in maize leaf chloroplasts, or the role of vitamin B5 on cancer tumor proliferation. Key take aways include: • Review the capabilities of the NanoSIMS for nanoscale chemical mapping in LIB samples • Observe the collocation of fluorine and phosphorus, and the increase in Li, P and F signals for aged LIB samples • Gain insight into LIB anode degradation processes and the challenges that lie ahead for enabling batteries with longer life-time and higher performane .
↓ Duration: 32 minutes
In this webinar Michael Kurczy discusses the development of the DrugSIMS™ platform. From the original blue sky initiative to embed a NanoSIMS in a pharmaceutical company to the eventual intracellular quantification of nucleic acid based therapeutics.
↓ Duration: 18 minutes
In this webinar, Dr Silvio Rizzoli will present NanoSIMS Imaging of the Brain in Health and Disease.
↓ Duration : 41 minutes
Pr. Steinhauser reports on his investigation of metabolic processes including glucose, lipid and nucleic acid metabolism, and cell turnover with NanoSIMS.
↓ Duration: 49 minutes
Learn from Denis Fougerouse how two CAMECA instruments contributed to the discovery of a new kind of “invisible gold”!
NanoSIMS 50L ion microprobe at The University of Western Australia and the LEAP 3D Atom Probe Curtin University enabled to locate gold in pyrite crystals’ nanoscale defects - dislocations that are 100 000 times smaller that the width of a human hair!
Application Booklet - Instrumentation
